Kinetics of the antibody response to vaccination with an immune complex IBD vaccine in broilers using a commercial kit ELISA

Kinetics of the antibody response to vaccination with an immune complex IBD vaccine in broilers using a commercial kit ELISA

M. Paniago, C. Cazaban, F. Lozano, B. Alva, and Y. Gardin
Ceva Santé Animale, 10 Avenue de la Ballastière, Libourne, France

SUMMARY

Observations of the kinetics of the immune response to infectious bursal disease (IBD) in 2972 healthy commercial broiler flocks vaccinated with an immune-complex IBD vaccine at day of age during a four and a half year period (February/2009 to July/2013), and raised in different regions of the world, was assessed for antibody response at different processing ages (Ranging from 25 to 60 d of life) using a commercial ELISA test kit. The vaccinated flocks gradually turned serologically positive after 26 d of age reflecting the timing when the vaccine virus reached the bursa of Fabricius. From around 38 d onwards, nearly all vaccinated flocks were positive. The percentage of serologically positive flocks slaughtered at ages varying from 40 to 60 d was 98.4% and the presence of the vaccine strain (W2512) was randomly confirmed by RT-PCR.

INTRODUCTION

Infectious bursal disease (IBD) is a disease of chickens caused by an Avibirnavirus. From its first description in the early 60’s, the disease spread out to  almost all chicken producing countries in the world and the it still remains as one of the major concerns for producers.
Its prevention basically depends on the association of biosecurity and vaccination. The introduction of IBD vaccines that can be injected through in ovo or subcutaneous routes in the hatcheries has greatly changed the vaccination procedures all over the world. This article summarizes a study conducted over a period of four and a half years in which the kinetics of the antibody response to IBD was assessed in nearly 3,000 commercial broiler flocks vaccinated with an Immune Complex IBD vaccine in the hatcheries.

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